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KMID : 0360419760120020043
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Korean Journal of Pharmacology
1976 Volume.12 No. 2 p.43 ~ p.49
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Influence of Prostaglandin F₂α given intracerebroventricularly on the renal function of the rabbits
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Abstract
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The facts that PGE₂ produced diuresis in the rabbit when given into a lateral ventricle of the brain and that PGF_(2α) is abundantly found in the brain prompted us to investigate the effects of PGF_(2α) introduced directly into the ventricle on the renal function.
PGF_(2α) given intraventriculary in doses of 10 ㎍ and 100 ㎍ elicited prompt diuresis, 10-fold increase of sodium excretion and two-fold increment of potassium excretion. Free water reabsorption also increased along with the increased osmolar clearance. Neither renal plasma flow nor glomerular filtration rate did change significantly. This, along with the fact that the percentage of reabsorbed sodium filtered decreased from 99.5 to 93.9, indicates the tubular site of the diuretic and natriuretic action.
Atropine pretreatment did not influence the renal effects of intraventricular PGF_(2α). Intravenously administered PGF_(2α) in doses of 30 to 100 ㎍ did not produce any significant change in renal function. Intraventricular PGF_(2α) had no effect on the systemic blood pressure, whereas intravenous administration brought about a transient hypotension.
These observations suggest that PGF_(2α) induces diuresis and natriuresis via central mechanism, that the site of the action resides in renal tubules, and that the reabsorption of sodium is inhibited in the proximal tubule, possibly through mediation of certain humoral agent. Overall, it is suggested that PGF_(2α) might play a roll in regulating renal function through the center.
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